Friday, 30 September 2016
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Is it just midlife, or is your thyroid slowing down?
Hope for treatment of migraine
This throbbing headache can last for hours or even days. Although it affects more than 36 million Americans between the ages of 15 and 55, the exact cause of migraines is still largely unknown.
What is a migraine?
Migraines are different than regular headaches. Headaches can cause mild to severe pressure and aching on both sides of your head, and they can last anywhere from 30 minutes to a week. “A normal headache feels like someone put a belt around your head and is pressing on it,” says Dr. Carolyn Bernstein, a neurologist at Brigham and Women’s Hospital and assistant professor of neurology at Harvard Medical School. “You can usually work through it but they’re pretty annoying.”
The three most common types of headaches are: sinus headaches, cluster headaches, and tension headaches. Of these, tension headaches are the most common and are typically caused by stress, muscle strain, or anxiety.
On the other hand, a migraine is a recurrent, throbbing headache that often affects only one side of the head. In addition to pain behind the eyes or ears, migraines can cause nausea and vomiting, vision problems, and sensitivity to sounds and lights. Experts don’t know precisely what causes migraine, although some migraine sufferers can point to certain things that seem to trigger their migraines. “Family history is a big factor, but people have different sensitivities to different triggers,” says Bernstein. These other triggers can include age, sex, hormonal changes, food, alcohol, and poor sleep.
Migraines and light sensitivity
One of the most common symptoms of a migraine is an increased sensitivity to light, called migraine photophobia. This can be so pronounced that migraine sufferers often need total darkness to deal with the pain.
But a recent study published in the journal Brain: A Journal of Neurology suggests that certain colors of light might not be all bad. Researchers found that while migraine headaches are exacerbated by light in general, green light in particular might not be as disruptive as previously thought.
Throughout the study, researchers flashed different colors of light at people suffering from migraines to test changes in migraine intensity, pain rating, sensory perception, and the spread of the migraine from the original site.
Compared to red, blue, and white lights, green light reduced migraine intensity in more than 20% of patients. It was the only light that reduced pain intensity, while white, blue, and red significantly increased pain ratings and muscle tenderness. Finally, more patients described the migraine spreading beyond its point of origin when they were exposed to blue, amber, and red light compared to white and green light. “The green light was easier for people to tolerate, and some people even felt better after seeing it,” says Bernstein, who led the clinical side of the study. “Not everyone had the same response, but overall there were enough data to show green light was preferred.”
Although green light didn’t do anything to cure the headache, this study does open the door for more research and potential therapies using green light down the road.
How do we treat migraine headaches now?
Right now, green light might not be a viable migraine therapy. For now, medications that treat the symptoms of migraines, including pain and nausea, offer some relief.
However, physicians advise that the best option for treating a migraine is preventing one from occurring in the first place. Avoiding triggers, managing stress, and getting enough sleep are just a few of the steps people can take. But doctors advise that no one should suffer from migraines silently.
“People need to understand that there is treatment for acute migraines,” says Bernstein. “If they are impacting your life it is important to see someone who can specifically treat them.”
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Marijuana: Health effects of recreational and medical use
Marijuana is a mind-altering (psychoactive) drug. Similar to hemp, it comes from the cannabis plant. The plant’s primary drug effects come from the chemical delta-9-tetrahydrocannabinol, or “THC.” Marijuana is smoked, “vaped” (inhaling the vapor), or ingested in foods or teas. Over the last few decades, the concentration of THC in the cannabis plant has been increasing. In addition, the plant extracts are more potent.
Marijuana is often used for its “high,” and can make people feel more relaxed, alter the senses, and cause time distortion. It can also impair thinking, judgment, coordination, and memory. In some people, it may lead to paranoia or anxiety. Physical effects may include bloodshot eyes, dry mouth, slurred speech, and increased heart rate.
These sensations may last up to four hours after inhaling marijuana smoke, or up to 12 hours if consumed, though performance impairments may last for much longer.
Smoking marijuana can irritate the lungs and lead to breathing problems like cough, excess mucus, bronchitis, and worsening of conditions like asthma and cystic fibrosis. It is not clear if smoking marijuana is linked to lung cancer. Marijuana use during pregnancy can also harm a baby’s brain development.
We are learning more about the long-term effects of marijuana, and this leads to even more questions as we realize there is a lot we don’t know. What is clear is that some of the long-term effects correspond to heavy use. However, heavy use is difficult to define given the nature and limitations of past studies, the different ways marijuana and its extracts are used, and the shifts in THC concentration in cannabis.
The biggest health risks appear to be in those who start using as teenagers or young adults when their brains are still developing. In youths who use heavily, studies have shown deterioration in their learning and cognitive thinking that persists into adulthood, even after they have stopped using marijuana. There also appears to be a link between marijuana use and certain mental illnesses. Though most marijuana users will not develop dependence and addiction, it is more common in teenage users.
Medical use of marijuana (“medical marijuana”) is somewhat controversial. In the United States, current FDA-approved medications containing synthetic THC are dronabinol (Marinol capsules, Syndros liquid) and nabilone (Cesamet). These drugs are prescribed as appetite stimulants in AIDS patients and for chemotherapy-related nausea and vomiting. They are sometimes used off-label for similar symptoms in other conditions. An oral spray nabiximols (Sativex) is approved in other countries for treatment of multiple sclerosis muscle spasticity and cancer-related pain not managed by other pain medication, and is undergoing further evaluation in the U.S.
Although marijuana can help relieve the symptoms of certain medical conditions, its use is still illegal on a federal level, and because we don’t have data from large, long-term, well-designed studies, the FDA continues to have concerns about potential risks versus benefits. Fortunately, studies continue on marijuana, THC, and cannabidiol (a component of marijuana which does not have the mind-altering effects of THC). Early research shows cannabidiol and its derivatives hold potential promise in additional conditions like drug-resistant epilepsy and some psychiatric disorders (e.g., anxiety, substance use disorders, schizophrenia, and psychosis).
Some states have passed laws, contrary to federal laws, to allow the use of marijuana for medical conditions. Some states have also made the move to decriminalize marijuana use by adults or have similar measures on upcoming ballots. It is unclear what health impact decriminalization of marijuana would have. The experiences of other states and countries that have made these legal changes were varied and unpredictable. The greatest threat would be an increase in adolescent use.
In the meantime, if you do use marijuana products, do not do so before driving or operating other heavy or dangerous equipment, and stop if you are pregnant. Talk to your doctor about the safety of continued use if you have a heart or lung condition, or are concerned that you might have developed an addiction. Avoid products that are packaged as candy or other edibles if there are children in your household who are more susceptible to a toxic overdose. And talk to your kids about the potential hazards of marijuana, because the risks are particularly high in young people.